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Low Level Laser Therapy (LLLT) for Orofacial Pain

Seyyed Amir Seyyedi, Pooya Olyaee, Zohreh Dalirsani, Farnaz Falaki




Low-power lasers are a group of lasers with a power less than 500 mW and unlike high-power lasers they have no effect on tissue temperature; they produce light-dependent chemical reactions in tissues. The purpose of this study was to review the clinical applications of these lasers and their success rate in different studies in orofacial pains. The articles with the key word “low level laser therapy” were extracted from pubmed. Clinical trials, meta-analysis, randomized clinical trials, and review articles were selected. Related articles to orofacial region were gathered and selected from the search results and carefully reviewed. Laser therapy may affect many cellular and sub-cellular processes, although exact mechanism has not been well-defined yet. Articles had different points of views as mentioned in the context of this article. Low level laser therapy was effective in orofacial pain relief in most studies, but the use of laser remains controversial. These lasers have analgesic features, and it is according to these features they have been used in the treatment of orofacial pain, Including myofacial pain, mucositis, facial myalgia, temporomandibular joint disorders and neuralgia. It seems that laser therapy can be considered as an alternative physical modality in treatment of orofacial pain.


orofacial pain; low level laser therapy; mucositis; neuralgia


Khalighi HR, Anbari F, Taheri JB, Bakhtiari S, Namazi Z, Pouralibaba F. Effect of Low-power Laser on Treatment of Orofacial Pain. J Dent Res Dent Clin Dent Prospect 2010; 4(3):75-8.

Al-sharify AA. The Biological Effects of Low Level Laser Therapy with Static Magnetic Field on Acute and Chronic Pain. Eng. & Tech 2007; 25(10):1154-61.

Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM. Efficacy of Low-Level Laser Therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. Lancet 2009; 374(9705):1897-908.

Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes- Martins RA. Low-Level Laser Therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 2006; 24(2): 158-68.

Dundar U, Evicke D, Samli F, Pusak H, Kavuncu V. The effect of Gallium laser therapy in the management of myofacial pain syndrome. Clin Rheumathol 2007 Jun;26(6):930-4.

Bradly P, Heller G. The effect of 830 nm laser on chronic myofacial pain. Pain 2006; 124:201-10.

Ilbuldu E, Cakmak A, Disci R, Aydin R. Comparison of laser, dry needling, and placebo laser treatments in myofascial pain syndrome. Photomed Laser Surg 2004; 22(4):306-11.

Irnich D, Behrens N, Gleditsch JM, Stor W, Schreiber MA, Schops P, et al. Immediate effects of dry needling and acupuncture at distant points in chronic neck pain: results of a randomized, double-blind, sham-controlled crossover trial. Pain 2002; 99(1-2):83-9.

Kulekcioglu S, Sivrioglu K, Ozcan O, Parlak M. Effectiveness of low-level laser therapy in temporomandibular disorder. Scand J Rheumatol 2003;32(2):114-8.

Altafini, Catro G, Ambrosio F. Diode laser in myofacial pain. Clin J Pain. 1998; 5:301-4.

Shirani AM, Gutknecht N, Taghizadeh M, Mir M. Lowlevel laser therapy and myofacial pain dysfunction syndrome: a randomized controlled clinical trial. Lasers Med Sci 2009;24(5):715-20.

Öz S; Gökçen-Röhlig B, Saruhanoglu A, Tuncer EB. Management of myofascial pain: low level laser therapy versus occlusal splints. J Craniofac Surg 2010. 21(6):1722-8.

Ribeiro Ms. Clinical evaluation of the low intensity laser antalgic action of Ga Al As in the treatment of the temporomandibular disorder. Laser Med Surg 2002; 18:205-7.

Emshoff R, Bosch R, Pumpel E, Schoning H, Strobl H. Lowlevel laser therapy for treatment of temporomandibular joint pain: a double-blind and placebo-controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105(4); 452-6.

da Cunha LA, Firoozmand LM, da Silva AP, Camargo SE, Oliveira W. Efficacy of low-level laser therapy in the treatment of temporomandibular disorder. Int Dent J 2008; 58(4):213-7.

Sakurai Y, Yamaguchi M, Abiko Y. Inhibitory effect of lowlevel laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 2000; 108(1): 29-34.

Bjordal JM, Couppé C, Chow RT, Tunér J and Ljunggren EA. A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother 2003; 49(2): 107-16.

Van Breugel HH, Bar PR. Power density and exposure time of HeNe laser irradiation are more important than total energy dose in photobiomodulation of human fibroblasts in vitro. Lasers Med Surg 1992;12(5): 528-37.

Eckerdal A, Bastin L. Can low reactive-level laser therapy be used in treatment of neurogenic facial pain? A double blind placebo controlled investigation of patients with trigeminal neuralgia. Laser Therapy 1996; 247-52.

Moore KC, Kramer P, Jayakumar C, Double blind crossover trial of low level laser therapy in the treatment of post herpetic neuralgia Neuropathic pain. Laser Therapy 1988; 1: 7.

Arun Maiya G, Sagar MS, Fernandes D. Effect of low level helium-neon laser therapy in the prevention and treatment of radiation induced mucositis in head and neck cancer patients. Indian J Med Res 2006; 124:399-402.

Schubert MM, Eduardo FP, Guthrie KA, Franquin JC, Bensadoun RJ, Migliorati CA, et al. A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation. Support Care Cancer 2007; 15(10):1145-54.

Bjordal JM, Bensadoun RJ, Tunèr J, Frigo L, Gjerde K, Lopes-Martins RA. A systematic review with metaanalysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis. Support Care Cancer 2011; 19(8):1069-77.

DOI: https://doi.org/10.22037/jlms.v3i3.2769